About
The Wilson lab is a collaborative group of physicians and scientists working to translate our research into precision medicines for patients with kidney dise...
Sitemap
A list of all the posts and pages found on the site. For you robots out there is an XML version available for digesting as well.
Pages
The Wilson lab at the University of Pennsylvania uses cutting edge technologies like single cell sequencing and spatial profiling to develop new therapies fo...
Positions
The Wilson lab is a collaborative group of physicians and scientists working to translate our research into precision medicines for patients with kidney dise...
Selected Publications
The Wilson lab is committed to open science. We strive to make our manuscripts, data and analysis available to the research community.
Software and Repositories
The Wilson lab is committed to open and reproducible data analysis. We develop software, workflows and containerized environments that we make available to t...
Posts
The Wilson lab is always on the move. Catch up with us as we engage with the research community.
Posts
Dr. Parker Wilson interviewed on ThermoFisher Absolute Gene-ius Podcast
ThermoFisher recently interviewed me for their Absolute Gene-ius podcast to learn about how the Wilson lab has been using digital PCR to study somatic mosaic...
Wilson lab is awarded an R21 catalytic tools and technology grant from the NIDDK
The Wilson lab partnered with the laboratory of Dr. Nancy Zhang at the University of Pennsylvania and was awarded an R21 catalytic tools and technology grant...
Wilson lab is awarded a George M. OBrien Kidney Resource Alliance Opportunity Pool Grant
The Wilson lab was one of six laboratories in the nation to receive a George M. O’Brien Kidney Resource Alliance (OKRA) Opportunity Pool Grant. This program ...
Wilson lab is awarded a pilot and feasibility grant from the Diabetes Research Center at Penn
The Wilson lab was awarded a pilot and feasibility grant from the Diabetes Research Center at Penn. This program is offered on a yearly basis and provides su...
Publication: Agraz et al. publish whole slide image normalization algorithms for digital pathology
Dr. Jose Agraz, a postdoctoral fellow in the Wilson lab, shows how H&E stain normalization can enhance integration of whole slide imaging datasets. Digit...
Publication: Wilson et al. publish single-cell analysis that shows mosaic loss of Y chromosome in the kidney
Wilson et al. used single-cell RNA, single-cell ATAC, and single-cell multiome (combined RNA + ATAC) sequencing to show that injured proximal tubule cells lo...
Dr. Parker Wilson receives Young Physician Scientist Award from ASCI
Dr. Wilson was among 50 physician-scientists to win a Young Physician Scientist Award (YPSA) from the American Society of Clinical Investigation. The ASCI Co...
Wilson lab opens its doors at Penn
The Wilson lab opens its doors on the 7th floor of the Stellar-Chance laboratories building
Publication: Multimodal single cell in DKD
Our manuscript on multimodal single cell in human diabetic kidney disease is now published in Nature Communications. Check out the tweetorial. parkercwilson...
Preprint: Multimodal single cell in DKD
Our preprint on multimodal single cell in human diabetic kidney disease is on bioRxiv. Check out the tweetorial.
people
Parker Wilson, MD, PhD
Dr. Wilson is a principal investigator in the Division of Diagnostic Innovation within the Department of Pathology and Laboratory Medicine.
Amit Verma, PhD
Amit is a postdoctoral fellow in the Wilson Lab. He is working on novel single-cell and digital PCR assays for quantification of somatic mosaicism in kidney...
Lisa Traczyk, BS
Lisa is a research specialist in the Wilson Lab. She is working on digital PCR assays for quantification of somatic mosaicism in kidney disease.
Hanzhi (Gary) Wang, MS
Gary is a pre-doctoral candidate in the Department of Bioengineering. He completed his undergraduate studies at Shanghai Jiao Tong University and the Univer...
publications
The single-cell transcriptomic landscape of early human diabetic nephropathy
Abstract Diabetic nephropathy is characterized by damage to both the glomerulus and tubulointerstitium, but relatively little is known about accompanying ...
Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney
Abstract The integration of single cell transcriptome and chromatin accessibility datasets enables a deeper understanding of cell heterogeneity. We perfor...
Multimodal single cell sequencing of human diabetic kidney disease implicates chromatin accessibility and genetic background in disease progression
Abstract The proximal tubule is a key regulator of kidney function and glucose metabolism. Diabetic kidney disease leads to proximal tubule injury and cha...
Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease
Abstract Mosaic loss of Y chromosome (LOY) is the most common chromosomal alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to sho...
Optimized Whole-Slide-Image H&E Stain Normalization: A Step Towards Big Data Integration in Digital Pathology
Abstract In the medical diagnostics domain, pathology and histology are pivotal for the precise identification of diseases. Digital histopathology, enhanc...
software
Pipeline for integrated snRNAseq and snATACseq analysis of healthy kidney
Abstract Muto and Wilson et al. Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney
🌶️SALSA - Single Cell Allele-Specific Analysis
Abstract Here you will find a workflow to analyze single cell allele-specific expression and chromatin accessibility obtained from 10X Genomics Single Cel...
Containerized workflow for analysis of human diabetic kidney disease by snRNA-seq and snATAC-seq
Abstract Wilson and Muto et al. Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease pro...
Containerized workflow for single cell detection of loss of Y chromosome and other mosaic chromosomal alterations in chronic kidney disease
Abstract Wilson et al. Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease