Preprint: Multimodal single cell in DKD

Our preprint on multimodal single-cell sequencing of human diabetic kidney disease is on bioRxiv. We paired snRNA-seq and snATAC-seq of early diabetic kidneys to show how changes in chromatin accessibility and genetic background shape the response of the proximal tubule to diabetes.

The work was later published in Nature Communications (2022). Read the published paper, browse the data on GEO (GSE195460), or reproduce the analysis with our containerized workflow.