Wilson lab receives its first NIDDK R01 to study DCLK1 isoform switching in kidney disease
The Wilson lab has been awarded an R01 from the NIDDK, DCLK1 isoform switching and proximal tubule injury in kidney disease (2026–2031). Aging and CKD shift which DCLK1 isoforms injured proximal tubule cells express, and this may change how DCLK1 interacts with PDZ scaffold proteins to promote disease. The project will:
- Quantify DCLK1 isoforms in animal models with isoform-specific qPCR and long-read sequencing.
- Test DCLK1 kinase inhibitors.
- Map inflammatory signaling from DCLK1+ injured proximal tubule cells in human kidney with single-cell-resolution spatial transcriptomics.