Wilson lab is awarded an NIDDK R03 to study DCLK1 and the DNA damage response
The Wilson lab received an R03 award from the NIDDK, DCLK1 and regulation of the DNA damage response in proximal tubule injury. DCLK1 is a kinase best known from cancer biology that is overexpressed in injured proximal tubule cells. This project will measure the balance of long and short DCLK1 isoforms in human kidney and test whether DCLK1 inhibitors developed for cancer can be repurposed to dampen inflammatory signaling in chronic kidney disease.