Publication: TraceBind enables robust ATAC-seq footprinting with sample-specific Tn5 bias correction
Congratulations to first author Y. Lin and Wilson lab PhD candidate Gary Wang on their paper in Nature Communications, a collaboration with the Zhang lab. TraceBind corrects sample-specific Tn5 cleavage bias by fine-tuning a pretrained cleavage model on mitochondrial reads. This enables more accurate transcription factor footprinting in both bulk and single-cell ATAC-seq.